Respiratory viral diseases: access to RNA interference therapy

RNA interference for viral infections.

The treatment of viral infections has relied on pre-emptive vaccination or use of a limited range of anti-viral drugs. However, the majority of viruses have no available drugs and treatment is merely supportive. RNA interference (RNAi) offers the ability to directly and rapidly treat virus infections via the targeting of viral genes. Indeed, clinical trials have already been undertaken with pro...

RNA interference: a new alternative for rheumatic diseases therapy.

RNA interference (RNAi) is a post-transcriptional gene silencing mechanism preserved during evolution. This mechanism, recently described, is mediated by small double-stranded RNAs (dsRNAs) that can specifically recognize a target mRNA sequence and mediate its cleavage or translational repression. The use of RNAi as a tool for gene therapy has been extensively studied, especially in viral infec...

Feline Viral Upper Respiratory Diseases

an introduction to rna interference (rnai)

the discovery of rna interference (rnai) in recent years has revolutionized biological and medical research. rnai is the sequence-specific gene silencing triggered by double-stranded rna (dsrna). until a couple of years ago only biologists working with caenorhabditis elegans and plants could use rnai technology to gain insight into gene function……

[Respiratory sequelae of viral diseases: from diagnosis to treatment].

OBJECTIVE The objective of the present article is to present a review of the main clinical issues faced by pediatricians while defining the diagnosis, management and prognosis of postinfectious bronchiolitis obliterans. SOURCES Data from national and international scientific journals selected from the Lilacs and Medline databases. SUMMARY OF THE FINDINGS With the purpose of establishing the...